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Indeed, the year 2000 was a very good year for wine makers — and not just because it brought a bumper crop of cabernets, zinfandels, and chardonnays. Evidence of the far-reaching health benefits of wine continued to pour in from researchers around the world.

Heres a review of the good news for wine makers — and wine lovers:

Several reports in 2000 confirmed the glad tidings that wine — in moderation, of course — reduces the risk ofcardiovascular diseaseandheart attacks. In the September issue of theAnnals of Internal Medicine, for instance, Swedish researchers at the Karolinska Institute reported that, compared to teetotalers, light drinkers who consumed wine cut their risk of dying prematurely by almost one third, and wine drinkers as a group had significantly lower mortality fromcardiovascular diseaseandcancer. Actually, drinking any kind ofalcoholicbeverage helped, the scientists found. But by far the biggest benefit accrued to wine drinkers.

Whats more, scientists are beginning to understand how wine may bestow its salutary benefits. For starters, according to findings published in the January 2000 issue ofEuropeanHeartJournal, this most ancient of beverages appears to dilatearteriesand increasebloodflow, thus lowering the risk of the kind of clots that cut offbloodsupply and damage heart muscles.

In addition, the fruit of the vine appears to boost levels of HDL, the goodcholesterol, and helps preventLDL, or badcholesterol, from causing damage to the lining of arteries. In a study published in the May 2000 issue of the journalPharmacology, Biochemistry, and Behavior, scientists at the Institute for Research in Extramural Medicine in Amsterdam tested 275 men and women around the age of 32. Those who imbibed the equivalent of a glass or two of wine each day had significantly higher levels of goodcholesterolbecause they remove the bad artery-clogging LDLs before they have a chance to choke blood vessels. Indeed, wine seems to facilitate that process, making it easier for HDLs to hustle their dangerous counterparts out of the bloodstream.

Yet even when LDLs remain behind in the arteries, substances in wine called phenols appear to help prevent the bad cholesterol from causing injury. In the November 2000Journal ofNutritionand Biochemistry, Italian researchers from the National Institute for Food andNutritionResearch reported that phenols seem to limit the oxidation of LDLs, making them less capable of damaging the linings of arteries and, therefore, less able to set the stage forcardiovascular disease, likeheart diseaseandstroke.

Wine also may protect against several forms of another common killer:cancer. It turns out that the same phenolic compounds that lowerheart disease riskalso may slow the growth ofbreast cancercells, according to findings reported by scientists at the University of Crete in Greece in the June 2000 issue ofJournal of Cellular Biochemistry. Phenols also were shown to suppress the growth ofprostate cancercells. And French scientists found evidence that an antioxidant in wine calledresveratrolcan put the brakes on the growth ofliver cancercells, according to a report in the July-August 2000 issue ofOncology Reports.

There also was a report that wine — particularly red wine — might help ward offoral cancer. Researchers from the University of Missouri School of Dentistry discovered that resveratrol and another antioxidant called quercetin may inhibit the growth of oral cancer cells. Their findings, published in the June 2000Journal of the American Dental Association, note that red wine is loaded with a slew of otherantioxidantsthat seem to boost itscancer-fighting abilities.

But perhaps the most startling news of all came in studies suggesting that moderate drinkers may cut their risk ofosteoporosis– age-related bone thinning related tocalciumloss. A report in theAmerican Journal of Epidemiologyin April 2000 showed that women who drank 11 to 29 grams of alcohol a day — the equivalent of one to three glasses of wine — had greaterbone mineral density, measured in the hip region of their thighbones, than nondrinkers or heavy drinkers. Bone mineral density is the measure physicians use to determine bone strength and resilience.

That news was quickly followed by an equally encouraging report in November in theAmerican Journal of Clinical Nutrition. Testing nearly 500 elderly women, researchers from Creighton University in Omaha, Neb., found that bone mineral density was 12% to 16% higher among moderate drinkers, compared with nondrinkers.

And women arent the only ones who may benefit. In a study published in the journalOsteoporosisInternationalin November 2000, Finnish scientists tested 143 men aged 54-63. Compared to nondrinkers, the men who enjoyed a glass or two of alcohol a day also showed signs of greater bone mineral density.

A healthy heart. Protection against cancer. Stronger bones. With health benefits like those, youd think doctors would be handing outprescriptionsfor wine by the padful.

Yet despite the encouraging findings, many physicians are reluctant to advise nondrinkers to begin drinking. With good reason: While moderate drinking appears to offer some impressive health benefits, excessive drinking can be deadly. It remains a sad truth that hundreds of thousands of Americans die ofliverdisease and in automobile accidents caused by drunk drivers every year.

Even the health benefits associated with wine disappear when people drink too much. For example, the studies cited above indicating greater bone density for women who were moderate drinkers also found that those who drank to excess may actually have had thinner bones by comparison. And not surprisingly, the results from the Seven Countries Study published in theInternational Journal of Epidemiologyin August 2000 suggested that heavy drinkers died almost two years earlier on average than moderate drinkers, although (perhaps surprisingly) the moderate drinkers outlived the nondrinkers by the same amount.

So far, theres little agreement on exactly what moderate drinking means. Until medical science is better at defining the right amount, limiting yourself to only two glasses a day if youre a man, and one if youre a woman, and then only after discussing it with your physician, is probably prudent.

To life, the traditional drinking toast goes. To which most researchers would add another: In moderation.

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