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Common Brand(S): Aleve, Anaprox, Naprosyn

Nonsteroidal anti-inflammatory drugs (includingnaproxen) may rarely increase the risk for aheart attackorstroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater in older adults or if you haveheart diseaseor increasedrisk for heart disease(for example, due tosmokingfamily historyofheart disease, or conditions such ashigh blood pressureordiabetes). Do not take this drug right before or afterheart bypass surgery(CABG).

This drug may rarely cause serious (rarely fatal) bleeding from thestomachorintestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.

Stop taking naproxen and get medical help right away if you notice any of these rare but serious side effects:stomachabdominal painthat doesnt go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusualsweating, confusion,weaknesson one side of the body, trouble speaking, suddenvisionchanges.

Talk to your doctor orpharmacistabout the benefits and risks of taking this drug.Uses

See also Warning section.Naproxenis used to relieve pain from various conditions such asheadache, muscle aches,tendonitis, dental pain, andmenstrual cramps. It also reduces pain, swelling, andjoint stiffnesscaused byarthritisbursitis, andgoutattacks. Thismedicationis known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your bodys production of certain natural substances that causeinflammation.If you are treating a chronic condition such asarthritis, ask your doctor about non-drug treatments and/or using othermedicationsto treat your pain.Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

If you are taking the over-the-counter product, read all directions on the product package before taking thismedication. If your doctor has prescribed this medication, read the Medication Guide provided by yourpharmacistbefore you start takingnaproxenand each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication bymouthas directed by your doctor, usually 2 or 3 times a day with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To preventstomachupset, take this medication with food, milk, or an antacid.

The dosage is based on your medical condition and response to treatment. To reduce your risk ofstomachbleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed by your doctor or the package label. For ongoing conditions such asarthritis, continue taking this medication as directed by your doctor.

For certain conditions (such asarthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

If you are taking this drug as needed (not on a regular schedule), remember that painmedicationswork best if they are used as the firstsigns of painoccur. If you wait until the pain has worsened, the medication may not work as well.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. If you are using the nonprescription product to treat fever, consult the doctor right away if the fever worsens or lasts more than 3 days.Side Effects

Upset stomachnauseaheartburnheadache, drowsiness, ordizzinessmay occur. If any of these effects last or get worse, tell your doctor orpharmacistpromptly.

If your doctor has directed you to use thismedication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise yourblood pressure. Check yourbloodpressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, difficult/painful swallowing, hearing changes (such asringing in the ears), mental/mood changes, signs ofkidneyproblems (such as change in the amount of urine), unexplainedstiff neckvisionchanges,symptoms of heart failure(such as swellingankles/feet, unusual tiredness, unusual/sudden weight gain).

This drug may rarely cause serious (possibly fatal)liver disease. Get medical help right away if you have any symptoms ofliverdamage, including: nausea/vomitingthat doesnt stop, loss of appetite,stomachabdominal pain, yellowingeyesskindark urine.

A very seriousallergic reactionto this drug is rare. However, get medical help right away if you notice any symptoms of a seriousallergic reaction, including: fever,swollen lymph nodesrashitching/swelling (especially of the face/tongue/throat), severe dizziness,trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-.Precautions

Before takingnaproxen, tell your doctor orpharmacistif you are allergic to it; or toaspirinor otherNSAIDs(such asibuprofencelecoxib); or if you have any otherallergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using thismedication, tell your doctor or pharmacist your medical history, especially of:asthmaaspirin-sensitiveasthma(a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs),blood disorders(such asanemia), bleeding/clotting problems, growths in the nose (nasal polyps),heart disease(such as previousheart attack),high blood pressureliver diseasestroke, swelling (edema, fluid retention),stomach/intestinal/esophagusproblems (such as bleeding,heartburn, ulcers).

Kidneyproblems can sometimes occur with the use of NSAIDmedications, including naproxen. Problems are more likely to occur if you are dehydrated, haveheart failureorkidney disease, are an older adult, or if you take certain medications (see alsoDrug Interactionssection). Drink plenty of fluids as directed by your doctor to preventdehydrationand tell your doctor right away if you have a change in the amount of urine.

This drug may make you dizzy or drowsy. Alcohol ormarijuanacannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medicine may causestomachbleeding. Daily use of alcohol andtobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol andstop smoking. Ask your doctor or pharmacist about how much alcohol you may safely drink.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Usesunscreenand wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have/redness.

Some naproxen products contain salt (sodium). Tell your doctor if you are on a salt-restricted diet.

Before having surgery, tell your doctor ordentistabout all the products you use (includingprescription drugs, nonprescription drugs, and herbal products).

Older adults may be at greater risk for stomach/intestinal bleeding, kidney problems,heartattack, andstrokewhile using this drug.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks. Tell your doctor if you arepregnantor if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use inpregnancyfrom 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy.

This drug passes intobreastmilk and may have undesirable effects on a nursinginfant. Consult your doctor before breast-feeding.Interactions

Drug interactionsmay change how yourmedicationswork or increase your risk for serious side effects. This document does not contain all possibledrug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor andpharmacist. Do not start, stop, or change the dosage of any medicines without your doctors approval.

Some products that may interact with this drug are:aliskirenACE inhibitors(such ascaptoprillisinopril), angiotensin II receptor blockers (such aslosartanvalsartan),cidofovir, corticosteroids (such asprednisone),lithiumwater pillsdiureticssuch asfurosemide).

Thismedicationmay increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-plateletdrugs such asclopidogrelblood thinnerssuch asdabigatranenoxaparinwarfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirinNSAIDssuch ascelecoxibibuprofen, orketorolac). These drugs are similar tonaproxenand may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-doseaspirinto preventheart attackorstroke(usually 81-162 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Daily use of naproxen may decrease aspirins ability to preventheartattack/stroke. Talk with your doctor about the risks and benefits. Ask about other medications that can be used to treat pain/fever.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.Does naproxen oral interact with other drugs you are taking?Enter your medication into the WebMD interaction checkerCheck InteractionOverdose

If someone has overdosed and has serious symptoms such as passing out ortrouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-. Canada residents can call a provincial poison control center. Symptoms ofoverdosemay include: severestomach pain, extreme drowsiness,seizures.Notes

Do not share thismedicationwith others.

Lab and/or medical tests (such asblood pressurecomplete blood countliverkidneyfunction) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you havearthritis, lifestyle changes (such asweight lossif needed, strengthening/conditioning exercises) may help improve your flexibility andjointfunction. Consult your doctor for specific instructions.Missed Dose

If you are taking this drug on a regular schedule (not just as needed) and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep allmedicationsaway from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult yourpharmacistor local waste disposal company.

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List naproxen oral side effects by likelihood and severity

Does naproxen oral interact with other medications?

Should I avoid certain foods while taking naproxen oral?

What should I know regarding pregnancy, nursing and administering naproxen oral to children or the elderly?

What conditions does naproxen oral treat?

Select a condition to view a list of medication options

a type of joint disorder due to excess uric acid in the blood called gout

joint inflammatory disease in children and young adults

joint damage causing pain and loss of function

ankylosing spondylitis, a rheumatic disease causing pain and stiffness in backbone

inflammation of the sac surrounding the joint – bursitis

non-radiographic axial spondyloarthritis

Are you currently using naproxen oral?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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